This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Purified antibody in PBS with 0.05% sodium azide
4℃; -20℃ for long term storage
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using LRRK2 mAb against human LRRK2 (AA: 300-530) recombinant protein. (Expected MW is 29.3 kDa)
Figure 3:Western blot analysis using LRRK2 mAb against HEK293-6e (1) and LRRK2 (AA: 300-530)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using LRRK2 mouse mAb (green) and negative control (red).
Figure 5:Immunofluorescence analysis of Hela cells using LRRK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
For Research Use Only. Not for use in diagnostic procedures.