LRP8 Primary Antibody
Item Information
Catalog #
Size
Price
Description
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Product Overview
Entrez GenelD
7804
Aliases
MCI1; LRP-8; APOER2; HSZ75190
Clone#
6F6B6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human LRP8 (AA: extra 42-182) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.Mol Neurobiol. 2016 Dec;53(10):6608-6619.
2.Circ Cardiovasc Genet. 2014 Aug;7(4):514-20.
2.Circ Cardiovasc Genet. 2014 Aug;7(4):514-20.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using LRP8 mAb against human LRP8 (AA: extra 42-182) recombinant protein. (Expected MW is 41.4 kDa)
Western Blot
Figure 3:Western blot analysis using LRP8 mAb against HEK293 (1) and LRP8 (AA: extra 42-182)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of Ramos cells using LRP8 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.