LRP6 Primary Antibody

Item Information
Catalog #
Size
Price
Description

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Product Overview
Entrez GenelD
4040
Aliases
ADCAD2; STHAG7
Clone#
1A3F5
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human LRP6 (AA: extra 1198-1370) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.Cancer Biomark. 2017;19(2):151-159.
2.Int J Med Sci. 2014 May 2;11(7):685-90.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using LRP6 mAb against human LRP6 (AA: extra 1198-1370) recombinant protein. (Expected MW is 45 kDa)
Figure 2:Western blot analysis using LRP6 mAb against human LRP6 (AA: extra 1198-1370) recombinant protein. (Expected MW is 45 kDa)
Western Blot
Figure 3:Western blot analysis using LRP6 mAb against HEK293 (1) and LRP6 (AA: extra 1198-1370)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using LRP6 mAb against HEK293 (1) and LRP6 (AA: extra 1198-1370)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of HL-60 cells using LRP6 mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of HL-60 cells using LRP6 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.