LRP5 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; OPTA1; VBCH2
ProductOrderL
Clone#2B11
Entrez GenelD4041
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human LRP5 expressed in E. Coli.
MW179kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
1422-1615
Catalog#: 30336
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Images
Western Blot
Figure 1: Western blot analysis using LRP5 mAb against human LRP5 (AA: 1422-1615) recombinant protein. (Expected MW is 20.8 kDa)
Figure 1: Western blot analysis using LRP5 mAb against human LRP5 (AA: 1422-1615) recombinant protein. (Expected MW is 20.8 kDa)
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

References (references)
References (references)1. Bone. 2010 Apr;46(4):940-5.
2. Endocr J. 2009;56(4):625-31.