LRP1 Primary Antibody
|Aliases||APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human LRP1 (AA: 20-155) expressed in E. Coli.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|ICC (Immunocytochemistry)||1/200 - 1/1000|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 2:Western blot analysis using LRP1 mAb against human LRP1 (AA: 20-155) recombinant protein. (Expected MW is 40.8 kDa)
Figure 3:Western blot analysis using LRP1 mAb against HEK293 (1) and LRP1 (AA: 20-155)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 5:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using LRP1 mouse mAb with DAB staining.
Figure 6:Flow cytometric analysis of Jurkat cells using LRP1 mouse mAb (green) and negative control (red).
Figure 6:Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using LRP1 mouse mAb with DAB staining.
|Description||The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.|
|References (references)||1.J Biol Chem. 2014 Feb 14;289(7):4135-44. |
2.Aging (Albany NY). 2013 Nov;5(11):835-49.