KI67 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesKIA; Ki-67; MKI67
ProductOrderK
Clone#4A1
Entrez GenelD4288
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenSynthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human KI67, conjugated to KLH.
MW358kDa
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Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
Sequence
CEDLAGFKELFQTPG
Catalog#: 20354
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Images
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human lymph node (A), esophagus (B), lung cancer (C), rectum cancer (D), showing nuclear localization using KI67 mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human lymph node (A), esophagus (B), lung cancer (C), rectum cancer (D), showing nuclear localization using KI67 mouse mAb with DAB staining.
Product Overview
Description

Ki67, also known as MKI67, it is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

References (references)
References (references)1. Folia Histochem Cytobiol. 2007;45(4):357-66.
2. Tumori. 2008 May-Jun;94(3):389-97.