KDR Primary Antibody
KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
2. FEBS Lett. 2002 Feb 13;512(1-3):107-10.
3. EMBO J. 2001 Jun 1;20(11):2768-78.
![Figure 1: Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20394lwb.jpg?v=1666698835)
![Figure 2: Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20394icc.jpg?v=1666698835)
![Figure 3: Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20394fcm.jpg?v=1666698835)