KDR Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFLK1; CD309; VEGFR; VEGFR2
ProductOrderK
Clone#4B4
Entrez GenelD3791
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
MW152kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(20-764)/112.9
Catalog#: 20394
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Images
Western Blot
Figure 1: Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764).
Figure 1: Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764).
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 3: Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple).
Figure 3: Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple).
Product Overview
Description

KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

References (references)
References (references)1. Blood. 2004 Aug 1;104(3):788-94.
2. FEBS Lett. 2002 Feb 13;512(1-3):107-10.
3. EMBO J. 2001 Jun 1;20(11):2768-78.