IGFBP2 Primary Antibody
Item Information
Catalog #
Size
Price
Description
IGFBP2: insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
Product Overview
Entrez GenelD
3485
Aliases
IBP2; IGF-BP53
Clone#
1F6F6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Oncol Rep. 2005 Feb;13(2):341-5.
2. Prostate. 2005 Jun 15;64(1):9-19.
3. Bone. 2005 Dec;37(6):741-50.
2. Prostate. 2005 Jun 15;64(1):9-19.
3. Bone. 2005 Dec;37(6):741-50.
Product Image
Western Blot
Figure 1: Western blot analysis using IGFBP2 mouse mAb against truncated IGFBP2-His recombinant protein (1) and truncated IGFBP2 (aa40-328)-hIgGFc transfected CHO-K1 cell lysate (2).
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), recturn(B), prostate (C), colon cancer (D) showing cytoplasmic localization using IGFBP2 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.