IDH2 Primary Antibody
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
2.J Exp Clin Cancer Res. 2014 Apr 10;33:32.
![Figure 1:Western blot analysis using IDH2 mAb against human IDH2 (AA: 1-143) recombinant protein. (Expected MW is 42.2 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666rwb.jpg?v=1666704257)
![Figure 2:Western blot analysis using IDH2 mAb against HEK293 (1) and IDH2 (AA: 1-143)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666twb.jpg?v=1666704257)
![Figure 3:Flow cytometric analysis of Hela cells using IDH2 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666fcm.jpg?v=1666704257)
![Figure 4:Immunohistochemical analysis of paraffin-embedded colon cancer tissues using IDH2 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666ihc-1.jpg?v=1666704257)
![Figure 5:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using IDH2 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666ihc-2.jpg?v=1666704257)
![Figure 6:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31666ea.jpg?v=1666704257)