HDAC3 Primary Antibody
HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
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![Figure 1: Western blot analysis using HDAC3 mouse mAb against Hela (1), NIH/3T3 (2), C6 (3) and COS (4) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20259lwb.jpg?v=1666698661)
![Figure 2: Confocal Immunofluorescence analysis of Hela cells using HDAC3 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20259icc.jpg?v=1666698661)