GZMB Primary Antibody
Item Information
Catalog #
Size
Price
Description
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Product Overview
Entrez GenelD
3002
Aliases
C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
Clone#
2G12G7
Host / Isotype
Mouse / Mouse IgG2a
Immunogen
Purified recombinant fragment of human GZMB (AA: 21-247) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200-1/1000
ELISA
1/10000
References
1,J Leukoc Biol. 2019 Feb;105(2):297-306. 2,Mol Immunol. 2019 Oct;114:172-178.
Product Image
ELISA
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
WESTERN BLOT
Figure 2: Western blot analysis using GZMB mAb against human GZMB (AA: 21-247) recombinant protein. (Expected MW is 28.4kDa)
WESTERN BLOT
Figure 3: Western blot analysis using GZMB mAb against HEK293-6e (1) and GZMB (AA: 21-247)-hIgGFc transfected HEK293-6e (2) cell lysate.
IMMUNOHISTOCHEMISTRY
Figure 4: Immunohistochemical analysis of paraffin-embedded brain tissues using GZMB mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.