GSK3 alpha Primary Antibody

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Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Product Overview
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
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Western Blot
Figure 1: Western blot analysis using GSK3 alpha mouse mAb against Hela (1) and PC-3 cell lysate.
Figure 1: Western blot analysis using GSK3 alpha mouse mAb against Hela (1) and PC-3 cell lysate.
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of Hela cells using GSK3 alpha mouse mAb showing cytoplasmic localization.
Figure 2: Immunofluorescence analysis of Hela cells using GSK3 alpha mouse mAb showing cytoplasmic localization.
For Research Use Only. Not for use in diagnostic procedures.