This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Purified antibody in PBS with 0.05% sodium azide
4℃; -20℃ for long term storage
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using GMNN mAb against human GMNN (AA: FULL 1-209) recombinant protein. (Expected MW is 26.5 kDa)
Figure 3:Western blot analysis using GMNN mAb against HEK293-6e (1) and GMNN (AA: FULL 1-209)-hIgGFc transfected HEK293-6e (2) cell lysate.ell lysate.
Figure 4:Flow cytometric analysis of C6 cells using GMNN mouse mAb (green) and negative control (red).
Figure 5:Flow cytometric analysis of Hela cells using GMNN mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded colon cancer tissues using GMNN mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using GMNN mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.