GFI1 Primary Antibody

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Description

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.Expression of GFl1 ranges from the hematopoietic and lymphoid system, to sensory epithelia, lung and parts of the CNS.

Product Overview
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
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Western Blot
Figure 1: Western blot analysis using GFI1 mAb against HEK293 (1) and GFI1(AA: 2-250)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using GFI1 mAb against HEK293 (1) and GFI1(AA: 2-250)-hIgGFc transfected HEK293 (2) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.