GCG Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesGLP1; GLP2; GRPP; GCG
ProductOrderG
Clone#2F9
Entrez GenelD2641
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human GCG expressed in E. Coli.
MW21kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
FULL(1-180)
Catalog#: 30151
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using GCG mAb against HEK293 (1) and GCG(AA: 1-180)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using GCG mAb against HEK293 (1) and GCG(AA: 1-180)-hIgGFc transfected HEK293 (2) cell lysate.
Product Overview
Description

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.

References (references)
References (references)1. Int J Mol Med. 2008 Jul;22(1):127-32.
2. Physiol Behav. 2008 Aug 6;94(5):696-9.