GATA4 Primary Antibody

Item Information
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Description

GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.

Product Overview
Entrez GenelD
2626
Aliases
MGC126629
Clone#
6H10
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human, Rat
Immunogen
Purified recombinant fragment of human GATA4 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Mol Cell Cardiol. 2007 Dec;43(6):677-85.
2. Mol Cell Biol. 2000 Oct;20(20):7550-8.
3. EMBO J. 1997 Sep 15;16(18):5687-96.
Product Image
Western Blot
Figure 1: Western blot analysis using GATA4 mouse mAb against rat fetal heart (1) and adult heart (2) tissues lysate.
Figure 1: Western blot analysis using GATA4 mouse mAb against rat fetal heart (1) and adult heart (2) tissues lysate.
For Research Use Only. Not for use in diagnostic procedures.