FOS Primary Antibody
|Aliases||p55; AP-1; C-FOS|
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Immunogen||Purified recombinant fragment of human FOS expressed in E. Coli. |
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using FOS mAb against human FOS (AA: 116-298) recombinant protein. (Expected MW is 45.8 kDa)
Figure 2: Western blot analysis using FOS mouse mAb against HeLa (1), and HeLa (2) cell lysate.
Figure 3: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using FOS mouse mAb with DAB staining.
Figure 4: Immunohistochemical analysis of paraffin-embedded cerebellum tissues using FOS mouse mAb with DAB staining.
Figure 5: Flow cytometric analysis of HeLa cells using FOS mouse mAb (green) and negative control (red).
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
|References (references)||Mol Cell Biochem. 2010 Apr;337(1-2):53-63. |
Cancer Invest. 2009 Oct;27(8):816-24.