FGR Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesSRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
ProductOrderF
Clone#6G2
Entrez GenelD2268
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human FGR expressed in E. Coli.
MW56kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
2-100(10.6KD)
Catalog#: 20318
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Images
Western Blot
Figure 1: Western blot analysis using FGR mouse mAb against HL60 (1) Raw264.7 (2) cell lysate.
Figure 1: Western blot analysis using FGR mouse mAb against HL60 (1) Raw264.7 (2) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Spleen tissues using FGR mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Spleen tissues using FGR mouse mAb
Product Overview
Description

FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References (references)
References (references)1. Immunity. 2005 Feb;22(2):235-46.
2. Biochemistry. 2007 Oct 2;46(39):11023-32.