FGR Primary Antibody

Item Information
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Price
Description

FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Product Overview
Entrez GenelD
2268
Aliases
SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
Clone#
6G2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human, Mouse
Immunogen
Purified recombinant fragment of human FGR expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Immunity. 2005 Feb;22(2):235-46.
2. Biochemistry. 2007 Oct 2;46(39):11023-32.
Product Image
Western Blot
Figure 1: Western blot analysis using FGR mouse mAb against HL60 (1) Raw264.7 (2) cell lysate.
Figure 1: Western blot analysis using FGR mouse mAb against HL60 (1) Raw264.7 (2) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Spleen tissues using FGR mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Spleen tissues using FGR mouse mAb
For Research Use Only. Not for use in diagnostic procedures.