FGFR4 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesTKF; JTK2; CD334
ProductOrderF
Clone#7H1
Entrez GenelD2264
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
MW87.9kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(22-369)
Catalog#: 20328
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Images
Western Blot
Figure 1: Western blot analysis using FGFR4 mouse mAb against extracellular domain of human FGFR4 (aa22-369).
Figure 1: Western blot analysis using FGFR4 mouse mAb against extracellular domain of human FGFR4 (aa22-369).
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with FGFR4-hIgGFc using FGFR4 mouse mAb(green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with FGFR4-hIgGFc using FGFR4 mouse mAb(green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

References (references)
References (references)1. Br J Cancer. 2006 Jun 19;94(12):1879-86.
2. Diabetes. 2007 Oct;56(10):2501-10.