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FBLN5 Primary Antibody
|Aliases||EVEC; UP50; ARMD3; DANCE|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.\
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1: Western blot analysis using FBLN5 mouse mAb against truncated FBLN5-His recombinant protein.
Figure 2: Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and breast cancer (right) showing cytoplasmic localization with DAB staining using FBLN5 mouse mAb.
|Description||FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.|
|References (references)||1. Am J Hum Genet. 2003 Apr;72(4):998-1004.
2. Genome Res. 2003 Oct;13(10):2265-70
3. N Engl J Med. 2004 Jul 22;351(4):346-53.
4. Surgery. 2005 Aug;138(2):352-9.