FAK Primary Antibody

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Description

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a

Product Overview
Entrez GenelD
5747
Aliases
FAK; FADK; FAK1; FRNK; pp125FAK; PTK2
Clone#
10H7A6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human FAK expressed in E. Coli.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Biol Chem. 2009 Aug 21;284(34):22865-77.
2. Biochem Biophys Res Commun. 2009 Oct 16;388(2):301-5.
Product Image
Western Blot
Figure 1: Western blot analysis using FAK mAb against FAK(AA: 354-533)-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using FAK mAb against FAK(AA: 354-533)-hIgGFc transfected HEK293 cell lysate.
For Research Use Only. Not for use in diagnostic procedures.