ESR1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesER; ESR; Era; ESRA; NR3A1; DKFZp686N23123; ESR1
ProductOrderE
Clone#6B6
Entrez GenelD2099
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human ESR1 expressed in E. Coli.
MW66kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
130-339
Catalog#: 30099
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Images
Western Blot
Figure 1: Western blot analysis using ESR1 mouse mAb against MCF-7 (1), T47D (2) and SKBR3 (3) cell lysate.
Figure 1: Western blot analysis using ESR1 mouse mAb against MCF-7 (1), T47D (2) and SKBR3 (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues using ESR1 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues using ESR1 mouse mAb with DAB staining.
Immunofluorescence analysis
Figure 3: Immunofluorescence analysis of Hela cells using ESR1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 3: Immunofluorescence analysis of Hela cells using ESR1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Overview
Description

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

References (references)
References (references)1. Calcif Tissue Int. 2010 Jul;87(1):25-35.
2. Arch Gynecol Obstet. 2010 Jun 18.
3. Biochemistry. 2010 Jul 27;49(29):5978-88.