EphB6 Primary Antibody
EPH receptor B6 (EphB6), with 1006-amino acid protein(~ 110 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions in development. EphB6 is expressed both in a variety of embryonic and adult tissues. EphB6 is a unique member in the Eph family of receptor tyrosine kinases in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. EphB6 can both positively and negatively regulate cell adhesion and migration and tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.
Purified antibody in PBS containing 0.03% sodium azide.
4°C; -20°C for long term storage
Figure 1: Western blot analysis of Jurkat (1) and NIH/3T3 (2) cell lysate using EphB6 mouse mAb.
Figure 2: Immunohistochemical analysis of paraffin-embedded human bladder carcinoma (left) and return carcinoma (right) tissue, showing cytoplasmic localization using EphB6 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.