EIF2AK3 Primary Antibody
Item Information
Catalog #
Size
Price
Description
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Product Overview
Entrez GenelD
9451
Aliases
PEK; WRS; PERK; EIF2AK3
Clone#
5G5
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Autophagy. 2008 Apr 1;4(3):364-7.
2. J Biol Chem. 2008 Jun 20;283(25):17020-9.
3. Hum Mol Genet. 2008 Oct 15;17(20):3254-62.
2. J Biol Chem. 2008 Jun 20;283(25):17020-9.
3. Hum Mol Genet. 2008 Oct 15;17(20):3254-62.
Product Image
Western Blot
Figure 1: Western blot analysis using EIF2AK3 mAb against HEK293 (1) and EIF2AK3(AA: 929-1116)-hIgGFc transfected HEK293 (2) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.