EIF2AK3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPEK; WRS; PERK; EIF2AK3
ProductOrderE
Clone#5G5
Entrez GenelD9451
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human EIF2AK3 expressed in E. Coli.
MW125kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
929-1116
Catalog#: 30115
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Images
Western Blot
Figure 1: Western blot analysis using EIF2AK3 mAb against HEK293 (1) and EIF2AK3(AA: 929-1116)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using EIF2AK3 mAb against HEK293 (1) and EIF2AK3(AA: 929-1116)-hIgGFc transfected HEK293 (2) cell lysate.
Product Overview
Description

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

References (references)
References (references)1. Autophagy. 2008 Apr 1;4(3):364-7.
2. J Biol Chem. 2008 Jun 20;283(25):17020-9.
3. Hum Mol Genet. 2008 Oct 15;17(20):3254-62.