DKK3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesRIG; REIC
ProductOrderD
Clone#4G7
Entrez GenelD27122
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human DKK3 expressed in E. Coli.
MW38kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Monkey
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
full(1-350)
Catalog#: 30010
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Images
Western Blot
Figure 1: Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate.
Figure 1: Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) and negative control (purple).
Figure 2: Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) and negative control (purple).
Product Overview
Description

Dkk-3 (Dickkopf-3) is a member of the dickkopf family. It is a 350 amino acid secreted glycoprotein that is composed of an N-terminal signal peptide and two conserved cysteine-rich domains, which are separated by a 12 amino acid linker region. This secreted protein is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.

References (references)
References (references)1. Virchows Arch. 2009 Jun;454(6):639-46.
2. Gene. 2002 Jan 9;282(1-2):151-8.
3. J Urol. 2004 Mar;171(3):1314-8.