CRKL Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCRKL
ProductOrderC
Clone#5E12
Entrez GenelD1399
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CRKL expressed in E. Coli.
MW39kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
100-303
Catalog#: 30231
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using CRKL mAb against human CRKL (AA: 100-303) recombinant protein. (Expected MW is 60 kDa)
Figure 1: Western blot analysis using CRKL mAb against human CRKL (AA: 100-303) recombinant protein. (Expected MW is 60 kDa)
Flow cytometric
Figure 2: Flow cytometric analysis of NIH/3T3 cells using CRKL mouse mAb (blue) and negative control (red).
Figure 2: Flow cytometric analysis of NIH/3T3 cells using CRKL mouse mAb (blue) and negative control (red).
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

References (references)
References (references)1. Mol Cell Biol. 2009 Jun;29(11):3076-87.
2. Cell. 2009 Jul 23;138(2):389-403.