CHIT1 Primary Antibody

Item Information

Catalog #

Size

Price

Description

CHIT1:chitinase 1 (chitotriosidase). Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

Product Overview

Entrez GenelD

1118

Aliases

Chitotriosidase;CHI3; CHIT; FLJ00314; MGC125322; CHIT1

Clone#

1D9G2

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Product Applications

WB (Western Blot)

1/500 - 1/2000

ELISA

1/10000

References

1. Sarcoidosis Vasc Diffuse Lung Dis. 2007 Mar;24(1):59-64.
2. Clin Biochem. 2007 Mar;40(5-6):365-9.

Product Image

Western Blot

Figure 1: Western blot analysis using CHIT1 mouse mAb against truncated Trx-CHIT1 recombinant protein (1) and truncated CHIT1 (aa22-466)-hIgGFc transfected CHO-K1 cell lysate (2).

For Research Use Only. Not for use in diagnostic procedures.