CDKN1C Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesBWS; WBS; p57; BWCR; KIP2; CDKN1C
ProductOrderC
Clone#3E3
Entrez GenelD1028
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CDKN1C expressed in E. Coli.
MW57kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
214-316
Catalog#: 30130
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Images
Western Blot
Figure 1: Western blot analysis using CDKN1C mAb against HEK293 (1) and CDKN1C(AA: 214-316)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using CDKN1C mAb against HEK293 (1) and CDKN1C(AA: 214-316)-hIgGFc transfected HEK293 (2) cell lysate.
Product Overview
Description

The protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.Tissue specificity: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

References (references)
References (references)1. Cell Cycle. 2007 Mar 1;6(5):620-5.
2. Oncogene. 2008 Sep 25;27(43):5651-61.