CDKN1B Primary Antibody
Item Information
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Description
p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Product Overview
Entrez GenelD
1027
Aliases
KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B
Clone#
3D8
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CDKN1B expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Exp Mol Med. 2009 Nov 30;41(11):765-71.
2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18.
2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18.
Product Image
Western Blot
Figure 1: Western blot analysis using CDKN1B mAb against CDKN1B(AA: 1-198)-hIgGFc transfected HEK293 cell lysate.
For Research Use Only. Not for use in diagnostic procedures.