CD86 Primary Antibody
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.
3. Immunology. 2009 Nov;128(3):334-41.
![Figure 1: Western blot analysis using CD86 mouse mAb against L1210 (1) and MOLT-4 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30107lwb.jpg?v=1666699102)