CD86 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesB70; B7-2; LAB72; CD28LG2; MGC34413; CD86
ProductOrderC
Clone#1B3
Entrez GenelD942
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CD86 expressed in E. Coli.
MW52kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
269-329
Catalog#: 30107
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Images
Western Blot
Figure 1: Western blot analysis using CD86 mouse mAb against L1210 (1) and MOLT-4 (2) cell lysate.
Figure 1: Western blot analysis using CD86 mouse mAb against L1210 (1) and MOLT-4 (2) cell lysate.
Product Overview
Description

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.Tissue specificity: Expressed by activated B-lymphocytes and monocytes.

References (references)
References (references)1. Clin Exp Allergy. 2009 Dec;39(12):1852-6.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.
3. Immunology. 2009 Nov;128(3):334-41.