Mouse Monoclonal Antibody to CD51
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/dbdcac5095c5ecfe702864f3c54f22041bf9039f571abba8e0694a381681c62c.jpg?v=1666705431)
![Figure 2:Western blot analysis using CD51 mAb against human CD51 (AA: extra 31-189) recombinant protein. (Expected MW is 43.6 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/c928a96fc736eb974782b87bbe4e89f57760ba2aa68f8f090c99c2263fba9a31.jpg?v=1666705431)
![Figure 3:Western blot analysis using CD51 mAb against HEK293-6e (1) and CD51 (AA: extra 31-189)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/c50bdee2d111aad809b5f8a05f2cb04b70fbffcda975c655729ea925b5a7740c.jpg?v=1666705431)
![Figure 4:Flow cytometric analysis of B16 cells using CD51 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/79c06704a7097818bfc4ffb14ec9e622b1e7ba196d5117a7256d5c9a734b8bcc.jpg?v=1666705431)