CD49D Primary Antibody

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Description

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.

Product Overview
Immunogen
Purified recombinant fragment of human CD49D (AA: extra 833-977) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using CD49D mAb against human CD49D (AA: extra 833-977)) recombinant protein. (Expected MW is 42.6 kDa)
Figure 2:Western blot analysis using CD49D mAb against human CD49D (AA: extra 833-977)) recombinant protein. (Expected MW is 42.6 kDa)
Western Blot
Figure 3:Western blot analysis using CD49D mAb against HEK293 (1) and CD49D (AA: extra 833-977))-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using CD49D mAb against HEK293 (1) and CD49D (AA: extra 833-977))-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 4:Flow cytometric analysis of HL-60 cells using CD49D mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of HL-60 cells using CD49D mouse mAb (green) and negative control (red).
Western Blot
Figure 5:Western blot analysis using CD49D mouse mAb against HL-60 (1) cell lysate.
Figure 5:Western blot analysis using CD49D mouse mAb against HL-60 (1) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.