CD42B Primary Antibody

Item Information
Catalog #
Size
Price
Description

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Product Overview
Entrez GenelD
2811
Aliases
GP1BA; BSS; GP1B; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha
Clone#
6H6B11
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1.Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1821-8. 2.Thromb Haemost. 2015 Jan;113(1):107-17.
Product Image
Elisa
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using CD42B mAb against human CD42B (AA: extra 17-183) recombinant protein. (Expected MW is 44.2 kDa)
Figure 2:Western blot analysis using CD42B mAb against human CD42B (AA: extra 17-183) recombinant protein. (Expected MW is 44.2 kDa)
Western Blot
Figure 3:Western blot analysis using CD42B mAb against HEK293 (1) and CD42B (AA: extra 17-183)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using CD42B mAb against HEK293 (1) and CD42B (AA: extra 17-183)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot
Figure 4:Western blot analysis using CD42B mouse mAb against K562 (1), HL-60 (2), and Ramos (3) cell lysate.
Figure 4:Western blot analysis using CD42B mouse mAb against K562 (1), HL-60 (2), and Ramos (3) cell lysate.
Flow cytometric
Figure 5:Flow cytometric analysis of HL-60 cells using CD42B mouse mAb (green) and negative control (red).
Figure 5:Flow cytometric analysis of HL-60 cells using CD42B mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 31456

Inquire
Contact us to order bulk/custom
1-866-339-0871
510-740-3625
info@promab.com