CD3E Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesT3E; TCRE; FLJ18683; CD3E
ProductOrderC
Clone#4E2
Entrez GenelD916
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of CD3E expressed in E. Coli.
MW23kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
23-126
Catalog#: 30036
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Images
Western Blot
Figure 1: Western blot analysis using CD3E mouse mAb against Jurkat (1) cell lysate.
Figure 1: Western blot analysis using CD3E mouse mAb against Jurkat (1) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of Jurkat cells using CD3E mouse mAb (green) and negative control (purple).
Figure 2: Flow cytometric analysis of Jurkat cells using CD3E mouse mAb (green) and negative control (purple).
Product Overview
Description

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

References (references)
References (references)1. Nat Methods. 2005 Aug;2(8):591-8.
2. J Cell Physiol. 2006 Dec;209(3):695-700. Review.
3. J Biol Chem. 2006 Dec 1;281(48):36977-84. Epub 2006 Oct 5.