CD38 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesT10; CD38
ProductOrderC
Clone#6E12D4A12
Entrez GenelD952
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CD38 expressed in E. Coli.
MW34kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
43-300(Extra)
Catalog#: 20413
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Images
Western Blot
Figure 1: Western blot analysis using CD38 mouse mouse mAb against CD38-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using CD38 mouse mouse mAb against CD38-hIgGFc transfected HEK293 cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B),showing cytomembrane localization using CD38 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B),showing cytomembrane localization using CD38 mouse mAb with DAB staining.
Product Overview
Description

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

References (references)
References (references)1. Trends Biochem Sci. 1992 Dec;17(12):495.
2. J Cell Biol. 1999 Sep 6;146(5):1161-72.
3. Exp Hematol. 2002 Jun;30(6):582-9.
4. Mol Immunol. 2006 Mar;43(7):1029-39.