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CD352 Primary Antibody
|Aliases||SLAMF6; KALI; NTBA; KALIb; Ly108; NTB-A; SF2000|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human CD352 (AA: extra 22-226) expressed in E. Coli.|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD352 mAb against human CD352 (AA: extra 22-226) recombinant protein. (Expected MW is 49 kDa)
Figure 3:Western blot analysis using CD352 mAb against HEK293 (1) and CD352 (AA: extra 22-226)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of HL-60 cells using CD352 mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CD352 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using CD352 mouse mAb with DAB staining.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
|References (references)||1.Immunity. 2006 Oct;25(4):559-70.
2.J Biol Chem. 2004 Apr 30;279(18):18662-9.