CD204 Primary Antibody
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
2.Cancer Sci. 2013 Aug;104(8):1112-9.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31541ea.jpg?v=1666704137)
![Figure 2:Western blot analysis using CD204 mAb against human CD204 (AA: extra 275-451) recombinant protein. (Expected MW is 44.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31541rwb.jpg?v=1666704137)
![Figure 3:Western blot analysis using CD204 mAb against HEK293 (1) and CD204 (AA: extra 275-451)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31541twb.jpg?v=1666704137)
![Figure 4:Western blot analysis using CD204 mouse mAb against PC-2 (1), A549 (2), HepG2 (3), L-02 (4), and PANC-1 (5) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31541lwb.jpg?v=1666704137)
![Figure 5:Flow cytometric analysis of HL-60 cells using CD204 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31541fcm.jpg?v=1666704137)