CD18 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesLAD; MF17; LCAMB; LFA-1; ITGB2
ProductOrderC
Clone#10E12
Entrez GenelD3689
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of CD18 expressed in E. Coli.
MW85kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
Sequence
N
Catalog#: 20346
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Images
Immunofluorescence analysis
Figure 1: Confocal Immunofluorescence analysis of HL60 cells using CD18 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 1: Confocal Immunofluorescence analysis of HL60 cells using CD18 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Immunofluorescence analysis
Figure 2: Confocal Immunofluorescence analysis of BCBL-1 cells (left) and L1210 cells (right) using CD18 mouse mAb (red). Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Confocal Immunofluorescence analysis of BCBL-1 cells (left) and L1210 cells (right) using CD18 mouse mAb (red). Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

References (references)
References (references)1. Microcirculation. 2008 Aug;15(6):555-67.
2. Mol Immunol. 2008 Feb;45(3):709-18.
3. J Biol Chem. 2007 Aug 17;282(33):24310-9.