Mouse Monoclonal Antibody to CD151
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/c57906f736be916821b39f8c7a917efa8296eae2d7cd37060600047892ee4bd8.jpg?v=1666705559)
![Figure 2:Western blot analysis using CD151 mAb against human CD151 (AA: extra 113-221) recombinant protein. (Expected MW is 38.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/bcd3771e26f5e5f7dad0af060eaa87c471cc6a73d2aef5d81ff5c58ec88f0214.jpg?v=1666705559)
![Figure 3:Western blot analysis using CD151 mAb against HEK293-6e (1) and CD151 (AA: extra 113-221)-hIgGFc transfected HEK293-6e (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/ad69dc4232b5131b2c6e58ce8be2c5893d8add264ad7ad8d1c701ccc06a627d7.jpg?v=1666705559)
![Figure 4:Flow cytometric analysis of Hela cells using CD151 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/fe52a70e00e5540735ede251993ab5bc656df65f8a91d9d190f99db113cacb99.jpg?v=1666705559)
![Figure 5:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using CD151 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/c3c18d144d0720cfd1bf191de35ab92570ff55722aaced18ac41a65527d4a0bb.jpg?v=1666705559)
![Figure 6:Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using CD151 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/124ccd78515c86afe59d85ff2957c2f3c6f1866baee3e08697c17a5d457b89c8.jpg?v=1666705559)