CD148 Primary Antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
2.J Neurooncol. 2015 May;122(3):451-9.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31544ea.jpg?v=1666703878)
![Figure 2:Western blot analysis using CD148 mAb against human CD148 (AA: extra 36-210) recombinant protein. (Expected MW is 44.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31544rwb.jpg?v=1666703878)
![Figure 3:Western blot analysis using CD148 mAb against HEK293 (1) and CD148 (AA: extra 36-210)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31544twb.jpg?v=1666703878)
![Figure 4:Flow cytometric analysis of HL-60 cells using CD148 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31544fcm.jpg?v=1666703878)