Mouse Monoclonal Antibody to CD121B
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/b824522c75e6a790d2acc2428c5ae45b2e39c3062c64953a93ff2d27e0202a28.jpg?v=1666705432)
![Figure 2:Western blot analysis using CD121B mAb against human CD121B (AA: extra 14-343) recombinant protein. (Expected MW is 68.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/459c16e94dd574f938fd1ca6ad373f759a011168eb5cbd91a08521c48b44c7d0.jpg?v=1666705432)
![Figure 3:Western blot analysis using CD121B mouse mAb against Hela (1) and MCF-7 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/19c31ed390be05eee3a07e739b33bbf50f9a0894907ffef3a8be7e455ab62d7c.jpg?v=1666705432)
![Figure 4:Flow cytometric analysis of THP-1 cells using CD121B mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/27f2dc0630252a9d270f4f99e16bbaf13fc07177093e5c9a38c015b012fbb52c.jpg?v=1666705432)