CD118 Primary Antibody
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31820ea_337.jpg?v=1666704622)
![Figure 2:Western blot analysis using CD118 mAb against human CD118 (AA: 45-188) recombinant protein. (Expected MW is 42.3 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31820rwb_338.jpg?v=1666704622)
![Figure 3:Western blot analysis using CD118 mAb against HEK293 (1) and CD118 (AA: 45-188)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31820twb_339.jpg?v=1666704622)
![Figure 4:Flow cytometric analysis of THP-1 cells using CD118 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31820fcm_340.jpg?v=1666704622)