CCND3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCCND3
ProductOrderC
Clone#6H4
Entrez GenelD896
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CCND3 expressed in E. Coli.
MW32kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
11-208
Catalog#: 30186
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Images
Western Blot
Figure 1: Western blot analysis using CCND3 mouse mAb against NIH/3T3 (1) and Jurkat (2) cell lysate.
Figure 1: Western blot analysis using CCND3 mouse mAb against NIH/3T3 (1) and Jurkat (2) cell lysate.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

References (references)
References (references)1. Blood. 2008 Jun 15;111(12):5683-90.
2. Pathol Res Pract. 2008;204(8):589-97.