CASP3 Primary Antibody
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
PLoS One. 2013 May 2;8(5):e62303.
![Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30759ea.jpg?v=1666700875)
![Figure 2:Western blot analysis using CASP3 mAb against human CASP3 (AA: 29-175) recombinant protein. (Expected MW is 19.5 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30759rwb.jpg?v=1666700875)
![Figure 4:Flow cytometric analysis of Hela cells using CASP3 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30759fcm.jpg?v=1666700875)