C-Kit Primary Antibody

Item Information

Catalog #

Size

Price

Description

C-kit (CD117, 145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

Product Overview

Entrez GenelD

3815

Aliases

PBT; SCFR; C-Kit; CD117; KIT

Clone#

8D7

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of C-kit expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. Mojica WD et.alHistopathology. 2005 Nov;47(5):517-22.
2. Tong WD et.alInt J Colorectal Dis. 2005 Jul;20(4):363-7. Epub 2005 Feb 2.
3. Nakai Y et.alBiochem Biophys Res Commun. 2005 Nov 11;337(1):289-96.

Product Image

Western Blot

Figure 1: Western blot analysis using C-kit mouse mAb against truncated C-kit recombinant protein.

Immunohistochemical analysis

Figure 2: Immunohistochemical analysis of paraffin-embedded maligant mesenchymoma tissues, showing cytoplasmic localization using C-kit mouse mAb with DAB staining.

For Research Use Only. Not for use in diagnostic procedures.