BNP Primary Antibody

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Description

BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.

Product Overview
Entrez GenelD
4879
Aliases
BNP; NPPB
Clone#
8D5B4C11
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to aa (Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser) of human BNP, conjugated to KLH.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Dawson A. Struthers AD. Expert Opin Biol Ther. 2003, Feb, 3(1):107-12. Review.
2. Pfister R. Erdmann E. Schneider CA. Dtsch Med Wochenschr. 2003,May 2, 128(18):1007-12.
Product Image
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP1 mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP1 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.