BLNK Primary Antibody
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
2. Cancer Sci. 2008 Dec;99(12):2444-54.
![Figure 1: Western blot analysis using BLNK mAb against human BLNK (AA: 34-216) recombinant protein. (Expected MW is 60 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232rwb.jpg?v=1666699435)
![Figure 2: Western blot analysis using BLNK mouse mAb against NIH/3T3 (1) and BCBL-1 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232lwb.jpg?v=1666699435)
![Figure 3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using BLNK mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232ihc.jpg?v=1666699435)
![Figure 4: Immunofluorescence analysis of HepG2 cells using BLNK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232icc.jpg?v=1666699435)
![Figure 5: Flow cytometric analysis of NIH/3T3 cells using BLNK mouse mAb (green) and negative control (purple).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232fcm.jpg?v=1666699435)
![Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30232ea.jpg?v=1666699435)