BLK Primary Antibody

Item Information
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Description

BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Product Overview
Entrez GenelD
640
Aliases
MGC10442
Clone#
9D10B7
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of BLK expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Theresa Tretter, Ashley E. Ross, Dominic I. Dordai. J. Exp. Med., Dec 2003; 198: 1863.
Product Image
Western Blot
Figure 1: Western blot analysis using BLK mouse mAb against truncated BLK recombinant protein Raji cell lysate.
Figure 1: Western blot analysis using BLK mouse mAb against truncated BLK recombinant protein Raji cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast tissue (A), lymph tissue (B) and skin carcinoma (C), showing membrane localization using BLK mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast tissue (A), lymph tissue (B) and skin carcinoma (C), showing membrane localization using BLK mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.