BCL10 Primary Antibody
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
2.Pathol Int. 2013 Mar;63(3):176-82.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31535ea.jpg?v=1666704015)
![Figure 2:Western blot analysis using BCL10 mAb against human BCL10 (AA: 98-234) recombinant protein. (Expected MW is 40.9 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31535rwb.jpg?v=1666704015)
![Figure 3:Western blot analysis using BCL10 mAb against HEK293 (1) and BCL10 (AA: 98-234)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31535twb.jpg?v=1666704015)
![Figure 4:Flow cytometric analysis of HL-60 cells using BCL10 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31535fcm.jpg?v=1666704015)