BCL-2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesBcl-2; BCL2
ProductOrderB
Clone#8E12
Entrez GenelD596
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenSynthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.
MW26kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman, Mouse
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
Sequence
CGGGITLGAYLGHK
Catalog#: 30077
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Images
Flow cytometric
Figure 1: Flow cytometric analysis of 3T3L1 cells using BCL-2 mouse mAb (green) and negative control (purple).
Figure 1: Flow cytometric analysis of 3T3L1 cells using BCL-2 mouse mAb (green) and negative control (purple).
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using BCL-2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 2: Immunofluorescence analysis of NIH/3T3 cells using BCL-2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded colon cancer tissues (left) and human brain tissues (right) using BCL-2 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded colon cancer tissues (left) and human brain tissues (right) using BCL-2 mouse mAb with DAB staining.
Product Overview
Description

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.Tissue specificity: Expressed in a variety of tissues.

References (references)
References (references)1. J Biol Chem. 2010 Mar 26;285(13):9770-9.
2. Pharmacogenomics J. 2010 Feb 16.
3. J Int Med Res. 2009 Nov-Dec;37(6):1868-76.